Sequential Synthesis of Histidine-degrading Enzymes in Bacillus subtilis
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چکیده
منابع مشابه
Sequential synthesis of histidine-degrading enzymes in Bacillus subtilis.
L-Histidine induces the formation of the four enzymes constituting the histidine-degrading pathway in Bacillus subtilis. Studies of the kinetics of induction of histidase and of FGA hydrolase demonstrated that the two enzymes appear after induction in sequence, separated by a Z-min interval. The results of experiments in which chloramphenicol was used to arrest peptide bond formation indicate t...
متن کاملInduction and repression of the histidine-degrading enzymes of Bacillus subtilis.
In Baci2Zus subtilis a series of four enzymes is responsible for the degradation of L-histidine to ammonia, formamide, and L-glutamic acid. The third enzyme of the series was not investigated; the other three enzymes, histidase, urocanase, and formiminoglutamate hydrolase, are induced by r,-histidine and repressed by catabolites. Mutants can be found in which the three enzymes are constitutive ...
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An attempt was made to determine whether sporulation and inducible enzyme synthesis in Bacillus subtilis are controlled by the same mechanism of catabolite repression. By the use of a thymine-requiring strain, it has been shown that, whereas sporulation remained repressed unless chromosome replication proceeded to completion, the induction of the enzymes histidase, sucrase, and a-glucosidase pr...
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Effects of nutritional and hormonal treatments on the activities of rat liver histidine-catabolizing enzymes histidine pyruvate transaminase, histidase, and urocanase, have been examined and estimates have been made of the rates of induction and degradation of each enzyme. Histidase and urocanase activities were slightly elevated in animals fasted for 48 hours, but the transaminase was not affe...
متن کاملCross pathway regulation: effect of histidine on the synthesis and activity of enzymes of aromatic acid biosynthesis in Bacillus subtilis.
l-Histidine and, to a lesser degree, l-phenylalanine at concentrations of 10(-4)m inhibit the growth of leaky mutants (bradytrophs) of Bacillus subtilis that are deficient in the synthesis of p-hydroxyphenylpyruvate, the first intermediate specific to tyrosine synthesis. The inhibition can be overcome by growth factor amounts of l-tyrosine and p-hydroxyphenylpyruvate. Histidine and phenylalanin...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62961-8